Since joining the University of Florida in 2015, Dr. Rui Xiao has been at the forefront of research on chemosensory modulation of aging. Now an Associate Professor, Dr. Xiao’s work aligns seamlessly with the mission of the Florida Chemical Senses Institute (FCSI), where he investigates how sensory inputs impact organismal aging and longevity.
Dr. Xiao’s journey into this specialized field began during his Ph.D. studies, where he focused on transient receptor potential (TRP) ion channels, a group of proteins essential for sensing temperature and chemical stimuli. His postdoctoral research expanded upon this foundation, exploring how TRP channels influence aging through temperature regulation. This interest ultimately led him to UF and FCSI, where his lab now employs genetic model organisms, particularly C. elegans, to study aging and sensory biology.
The tiny nematode C. elegans serves as an ideal research model due to their short lifespan, fully mapped nervous system, and extensive genetic resources. Dr. Xiao’s studies have revealed how gut chemosensory receptors and transporters modulate intestinal function and overall aging, contributing to a growing body of research that links sensory biology to longevity. His most impactful work, published in Cell, demonstrated that temperature actively regulates lifespan through a specific genetic pathway rather than passive thermodynamic effects—findings that continue to shape the field.
Beyond his own research, Dr. Xiao is deeply committed to mentoring the next generation of scientists. One of his trainees, Zachary Markovich, a third-year graduate student and a fellow on the FCSI’s Chemosensory Sciences Training Program NIH/NIDCD T32, is currently investigating how gut chemosensory receptors and transporters influence aging. Dr. Xiao finds great fulfillment in guiding young researchers, considering their success a crucial part of his own academic achievements.
Collaboration is another key component of Dr. Xiao’s work at FCSI. He has worked closely with fellow researchers Dr. Jeff Martens and Dr. Hua Yan, securing research grants and furthering the institute’s mission. He believes that having an institute dedicated to chemical senses fosters an essential environment for advancing knowledge in taste, smell, and sensory physiology.
On a broader scale, Dr. Xiao’s research has far-reaching implications. As people age, their sense of taste and smell often declines, affecting nutrition, safety, and overall quality of life. Some studies even suggest a connection between olfactory decline and neurodegenerative diseases like Alzheimer’s. Understanding how the chemosensory system influences aging could lead to breakthroughs in health and longevity.
Dr. Xiao credits his mentors, family, and UF colleagues for their support throughout his career. To students entering the field, he offers this advice: “One of the most valuable pieces of advice I received from my Ph.D. and postdoctoral mentors was to maintain curiosity and stay positive throughout scientific exploration. I encourage all my students to embrace this approach as well.”
Looking ahead, Dr. Xiao hopes to continue inspiring others to explore the complexities of aging and sensory biology, leaving a lasting impact on both scientific understanding and human health.